EDITORIAL COMMENT How can tumor cells adhere to the surrounding tissues and form a progression or metastasis? Nowadays, there are many researches in the literature about this topic including adhesion molecules cell-adhesion molecules (CAMs). Cancer development and progression are aided by the environmental or genetic/epigenetic factors. As we know, not all cancer cells within tumors have equal tumor growth (the concept of cancer stem cells-CSCs and tumor cell heterogeneity) and it is a key factor for developing new anticancer therapeutics. CAMs have a major role in the interaction between CSC and extracellular matrix (ECM). Cadherins, integrins, selectins and members of immunoglobulin family constitute the major groups of CAMs. CAMs play an important role in cell-to-cell and cell-to-ECM anchoring by maintaining cell and tissue structure, cell signaling and tissue repair. They are dominant in the epithelial-to-mesenchymal transition, cell migration, gene regulation (as β-catenin/Wnt), cell proliferation, differentiation, wound healing, immune response, and regulation of inflammation. These molecules and transcription factors (twist, snail) have effects on progression and metastasis. Neoangiogenesis is equally responsible in the progression and metastasis. Recently, researches are focused on discovering  new antiangiogenic or antiadhesive therapeutics, such as bevacizumab, avastin, integrin inhibitors, and cadherin inhibitors. In the near future, more specific researches on adhesion molecules will provide opportunity for discovering new anticancer therapeutics.