Case Report

The Largest Cystic Nephroma Treated by Laparoscopic Nephron-sparing Surgery: A Case Report and Review of the Literature

10.4274/jus.galenos.2018.2190

  • Nejdet Karşıyakalı
  • Uğur Yücetaş
  • Hüseyin Aytaç Ateş
  • Sevim Baykal Koca
  • Ceyda Turan Bektaş
  • Mahmut Gökhan Toktaş

Received Date: 12.07.2018 Accepted Date: 30.10.2018 J Urol Surg 2019;6(2):148-151

Cystic nephroma is a rare benign tumour of the kidney. The symptoms are often non-specific and the diagnosis of the disease is usually made incidentally. Definitive diagnosis can be possible with histopathological evaluation. Surgical resection provides curative treatment. We report a successful removal of cystic nephroma in a 67-year-old female which was managed by laparoscopic nephron-sparing surgery. When a renal mass including multiple cystic formations is visualized on radiological imaging, the clinician should consider cystic nephroma for differential diagnosis, and these cases should be evaluated in terms of nephron-sparing surgery.

Keywords: Cystic nephroma, Laparoscopy, Partial nephrectomy, Renal cyst, Renal tumour

Introduction

Cystic nephroma is a mixed mesenchymal and epithelial neoplasm of the kidney which has a benign nature and tends to grow slowly (1). Despite the increased prevalence in children aged between 3 months and 2 years and in middle-aged adults (40-70), the prevalence has been reported to be 2.4% in the literature (2).

After being described by Edmunds first as cystic nephroma (3), various descriptions, such as “multilocular cystic tumor”, “renal multilocular cyst”, “multilocular cystic nephroma”, “renal cystic hamartoma”, “partial polycystic kidney” and “polycystic nephroma”, have been made in the literature (4). Some authors have argued that cystic nephroma was closely related with mixed epithelial and stromal tumors (MESTs) and even they might be the same clinical entity. The World Health Organization and the International Society of Urological Pathology Vancouver classifications collect these clinical entities under the same title (5,6).


Case Presentation

Written informed consent was obtained from patient who participated. A 67-year-old female patient was admitted to the urology outpatient clinic in November 2017 with the complaints of painless, unclotted hematuria and left lateral pain. She had a history of medical treatment due to hypertension and type 2 diabetes mellitus. The complete blood count, liver function, renal function and coagulation tests were found to be within the normal limits. On ultrasound imaging, a cystic mass was identified in the left kidney. On the dynamic magnetic resonance imaging , a multilocular cystic mass measuring 180x122x50 mm in size, showing an exophytic extension from the middle-lower pole was identified. Multiple septae were visualized in the mass; some of them were thick and irregular and showed contrast uptake. The cystic mass was graded as Bosniak category 3 (Figure 1). The patient underwent non-ischemic left laparoscopic partial nephrectomy operation in December 2017. Macroscopic view of the mass in the operating room after the excision is shown in Figure 2.

On pathological examination, macroscopic evaluation demonstrated a mass without solid area. The mass consisted of smooth, thin-walled cysts containing light yellow fluid in the lumen. The largest cyst was 5.5 cm in diameter. Histopathological examination revealed that the cystic structures were locally lined by stratified cuboidal epithelium and locally lined by hobnail cells (Figure 3). Immunohistochemically, all the epithelial cells lining the cystic structures stained positive for cytokeratin 19 and negative for CD10, carbonic anhydrase-9, and vimentin. While the stromal component stained positive for progesterone receptor and stained focally positive for estrogen receptor and smooth muscle actin, no staining was observed for desmin. With these histomorphologic results, the patient was diagnosed with MEST according to the 2016 World Health Organization classification of urogenital tumors. The appearance of the patient’s incision scar one month after the surgery is shown in Figure 4.


Discussion

Cystic nephroma accounts for approximately 1-2% of all renal masses (4). Nearly 200 cases of cystic nephroma have been presented in the literature over 125 years since its first description until today (7).

Cystic nephroma shows bimodal age distribution, two-thirds of patients are males in the first two years of childhood; a second increase in incidence is seen over 30 years of age with female predominance. No cystic formations are found in other organs (4). Likewise, our patient’s imaging revealed no cystic formation in other intraabdominal organs.

Although the etiologic factors are not clearly known, basically, the congenital factors are considered in childhood, whereas the acquired factors are considered to be preliminary in post-menopausal women (8). Steele et al. (9) described the similarities between tumor stroma and overian-stroma and they suggested that cystic nephroma may develop as a result of atypical localization of the Mullerian type tissue in the kidney.

In a review article by Granja et al. (10), the most common initial findings were according to the frequency order have been reported as a palpable mass (35.2%), incidental imaging finding (23.2%), abdominal pain (18.7%), hematuria (7.1%), non-specific symptoms (5.2%), and a palpable mass with hypertension (3.9%). In the same study, the authors have reported that the most common clinical presentation of cystic nephroma was unilateral solitary mass and that the median size of mass was 73 mm in patients aged 11 and older. Likewise, the symptoms of lateral pain, hematuria and hypertension were present in our patient during the clinical admission, but the largest diameter of the mass was found to be considerably higher than the median values reported in the literature.

Even if the multilocular characteristic of cystic nephroma can be revealed by imaging techniques, it is very difficult to distinguish Bosniak type 2 and 3 cysts. They are both visualized as cystic lesions with numerous septae on computed tomography, and sometimes calcification may be visualized on the cyst wall (7). Likewise, while a multilocular macroscopic appearance and findings consistent with calcification on the cyst wall were detected on the dynamic magnetic resonance imaging of our patient, it was demonstrated that the cysts were not related to each other and to the collecting system.

Although biopsy is not a routine approach in Bosniak category 3 cystic masses (11), the frequency of partial nephrectomy would be increased by preoperative biopsy or frozen section biopsy peroperatively, especially in case of suspected cystic nephroma. We considered cystic renal cell carcinoma (RCC) for the pre-diagnosis, so we did not perform a pre-operative biopsy. Further studies in the field of radiology may increase the prevalence of cystic nephroma in the pre-operative period and may assist urologists in managing the treatment.

The diagnostic criteria of cystic nephroma has been described by Powell as being unilateral, multilocular, absence of connection between the renal pelvis and cyst, absence of connection between cysts, presence of epithelium determining the border between cysts, absence of renal structure in cyst, and presence of intact renal tissue if present (12).

The differential diagnosis of cystic tumors includes non-neoplastic cystic renal diseases, multilocular cystic RCC, sarcomatoid RCC and nephroblastoma. In multilocular cystic RCC, clear cell conglomerations are found on the cyst wall and blastema is found in nephroblastoma. Cystic nephroma and MESTs of the kidney are benign lesions and show similar clinical, morphological and immunohistochemical characteristics. Jevremovic et al. (13) reported cystic nephroma and MEST as a single entity with varying stroma/cyst ratio. The main difference between these two entities is the rate of solid formation and the cellular content of stroma. While diffuse and thin-walled cysts are observed in cystic nephroma, MEST is a more solid tumor formation including relatively thicker-walled cysts with partial cystic formations (13).

Surgical resection provides a curative treatment. Sharma et al. (14) reported that they successfully treated a 99x82x81 mm cystic nephroma with left kidney lower pole localization by open partial nephrectomy. Sawant et al. (15) published their surgical techniques in a case which they treated the largest cystic nephroma reported in the literature (31x19x19.6 cm; 5.5 kg) by radical nephrectomy with a thoracoabdominal incision. We also treated the multilocular cystic, 180x128x50 mm sized mass, which was originated from the middle-lower pole of the left kidney, by laparoscopic partial nephrectomy with zero ischemia since it did not show adjacency to major vascular structures and had an exophytic characteristic. To the best of our knowledge, the largest cystic nephroma case underwent laparoscopic nephron-sparing surgery in the literature was our patient.

The current European Association of Urology guideline on RCC recommends performing nephron-sparing surgery in localized T1-T2 stage disease, independent of the surgical technique. It is reported that partial nephrectomy is also the best treatment approach for T2 stage tumors in suitable patients, although partial nephrectomy is primarily recommended in T1 stage disease. Nephron-sparing surgery has also been indicated for patients with a solitary kidney, poorly functioning contralateral kidney or any pathology in the contralateral kidney and a disease causing chronic, vascular damage such as hypertension and diabetes mellitus is present (11). In our case, multilocular cystic RCC was also present among our differential diagnoses, we deemed appropriate to perform laparoscopic nephron-sparing surgery because of the additional comorbidities mentioned above, although stage T2b was revealed by imaging techniques.


Conclusion

Cystic nephroma is a rare benign tumour of the kidney; its etiology is not clearly known, and it is often incidentally diagnosed due to non-specific symptoms. It is usually possible to make the definitive diagnosis only with histopathological examination. Although biopsy is not a routine approach in the preoperative period, the diagnosis can be confirmed by taking a biopsy in cases with a high probability of cystic nephroma.

When a renal mass including multiple cystic formations is visualized on radiological imaging, the clinician should consider cystic nephroma for differential diagnosis.

Laparoscopic nephron-sparing surgery is one of the surgical treatment options that can be performed by experienced surgeons in suitable cases for the treatment of cystic nephroma regardless of the size of the mass since it has a lower morbidity rate compared to open surgery.


Ethics

Informed Consent: Written informed consent was obtained from patient who participated.

Peer-review: Externally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: U.Y., N.K., H.A.A., S.B.K., C.T.B., Concept: N.K., Design: N.K., H.A.A., Data Collection and/or Processing: N.K., S.B.K., C.T.B., Analysis and/or Interpretation: M.G.T., Literature Research: N.K., H.A.A., Writing: N.K.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: None.

Images

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