EDITORIAL COMMENT In this large prospective, multicenter, international, large cohort study, the authors aimed to determine baseline characteristics of patients with penile implants according to the Prospective Registry of Outcomes with Penile Prosthesis for Erectile Restoration data. Between June 2011 and April 2015, a total of 1019 patients were enrolled in this study at 11 North American sites. The majority of the subjects (983) underwent implantation with AMS 700 IPP, of whom 495 received the LGX model. In addition, 26 patients received an AMS Ambicor and 10 underwent placement of an AMS Spectra. Radical prostatectomy (RP) was the major etiology (285 subjects, 28%), and the other etiologies were diabetes (220, 21.6%), cardiovascular disease (CD) (200, 19.6%) and Peyronie’s disease (PD) (91, 8.9%). Of those patients, 76.4% had placement of the reservoir in space of Retzius, and 21.7% had submuscular (infrafascial) below muscle. Patient’s hospital stay analysis revealed that 51.3% were under 24-hour observation, while 43.3% underwent same day discharge and only 5.3% were hospitalized for more than 24 hours. Among patients receiving an AMS 700, those treated with RP and diabetes had more outpatient admissions (less than 24 hours, 56.8% and 52.1%) compared to patients with CD and PD (42.0% and 35.6%). In conclusion, most of the patients receive a 3-piece IPP and RP is the most common primary etiology of penile implant surgery in North America. Moreover, patients who had undergone RP were more likely to have the reservoir placed in a submuscular location, experience a longer OR time and overnight stay in hospital compared with other patients groups.