Association between infertility and cancer is gaining importance. In this review article, relationships between male factor infertility and cancer are focused in the light of the recent literature. Developing testicular cancer and high grade prostate cancer risk in infertile men appear to be at least double compared to the general population. It has been demonstrated that male infertility can be a biomarker for cancer risk in first- and second-degree relatives. Moreover, testicular cancer risk in the first-degree relatives of infertile men is higher than in fertile controls. Male infertility has been shown to be associated with a two- to threefold elevation in the risk of childhood cancer in the siblings of infertile men. Extensive studies investigating the underlying genetic, epigenetic, environmental and hormonal mechanisms of the relationship between male infertility and cancer development will provide comprehensive counseling for infertile men and their families.
Re: Male Infertility: A Biomarker of Individual and Familial Cancer Risk
Urologic Survey
Re: Male Infertility: A Biomarker of Individual and Familial Cancer Risk
J Urol Surg 2018;5(1):54-54· DOI: 10.4274/jus.2018.05.004
Corresponding Author: Emre Bakırcıoğlu
Licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 (CC BY-NC-ND) International License.
CC BY-NC-ND — Attribution-NonCommercial-NoDerivatives 4.0 InternationalThe statements, opinions, and data contained in articles published in this journal are solely those of the individual author(s) and contributor(s) and do not necessarily reflect the views of the journal, its editors, editorial board, owner, or Galenos Publishing House.
Neither the journal nor Galenos Publishing House endorses or recommends any commercial product, process, service, institution, or organization that may be mentioned or advertised in the journal. The publication of advertisements, product information, or links to external websites does not constitute endorsement or approval by the journal or the publisher.
The journal, its editors, editorial board, owner, and Galenos Publishing House make reasonable efforts to ensure the accuracy and integrity of published content; however, they cannot be held responsible for errors, omissions, or any consequences arising from the use of information contained in the journal, to the extent permitted by applicable law.
Information published in the journal is intended for scientific and educational purposes and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Readers should consult appropriately qualified healthcare professionals regarding individual medical conditions or treatment decisions.
External links are provided for informational convenience only. The journal and Galenos Publishing House are not responsible for the availability, accuracy, content, privacy practices, or policies of external websites.
